STANDARD TREATMENT
Semaglutide Plus+
average 16.9% body weight loss
$299/mo
HSA / FSA Eligible
GLP-1 blend featuring a full dose of Semaglutide, enhanced with Cyanocobalamin (Vitamin B12) to support weight loss and boost energy levels.
Same active ingredient as Ozempic® & Wegovy®
In stock: Same day prescriptions and free overnight shipping
Each batch of medication undergoes extensive quality checks
What is Semaglutide Plus?

Meet Semaglutide Plus, our enhanced weight loss formula that combines the proven power of Semaglutide with Cyanocobalamin (Vitamin B12) to support your overall health and wellness. Specifically compounded for Willow patients, this unique blend offers more than just weight loss.

While Semaglutide works to suppress appetite and regulate blood sugar, Cyanocobalamin provides targeted benefits to complement your weight loss journey. It supports energy production, promotes nervous system health, and aids in red blood cell formation, helping you stay energized and reduce fatigue that can occur during weight loss.

Semaglutide Plus delivers a more comprehensive approach, helping you achieve your goals effectively while enhancing your overall vitality and well-being.

CA, WI, and IA residents will receive Semaglutide Plus with L-Carnitine. This GLP-1 blend features a full dose of Semaglutide, enhanced with L-Carnitine to support weight loss and preserve lean muscle mass.

What are the benefits of L-Carnitine?

L-Carnitine is a naturally occurring amino acid that plays a critical role in your body’s ability to burn fat and produce energy. It works by transporting fatty acids into your cells, where they can be converted into usable energy, helping boost fat metabolism. This makes L-Carnitine an excellent supplement for those looking to enhance their weight loss efforts.

When combined with Semaglutide, L-Carnitine offers even greater benefits. While Semaglutide helps regulate blood sugar and control appetite, L-Carnitine ensures that your body efficiently burns fat without compromising muscle mass. This combination supports steady, sustained weight loss while helping maintain muscle strength, which can be a challenge during rapid weight loss. Together, Semaglutide and L-Carnitine create a powerful synergy that not only helps you lose weight but also preserves lean muscle, giving you better long-term results and improved overall health.

What is the difference between Semaglutide and Tirzepatide

Semaglutide and tirzepatide are both medications used for weight loss, but they have distinct differences.

Semaglutide is a GLP-1 receptor agonist, which helps to regulate blood sugar by enhancing insulin secretion, slowing gastric emptying, and promoting satiety.

Tirzepatide, on the other hand, is a dual agonist, targeting both the GLP-1 and GIP receptors, offering enhanced glucose control and weight loss by combining the effects of both incretin hormones. Clinical trials suggest that tirzepatide offers superior efficacy in both glucose lowering and weight reduction compared to semaglutide.

Lose 15% of body weight with weight loss that feels natural
The science behind Semaglutide Plus

When you eat, the food stimulates your gut to release the GLP-1 hormone. GLP-1 helps lower blood glucose (blood sugar) by triggering insulin release. Insulin helps blood glucose enter your body’s cells for later energy use.

In some people, the gut doesn't make enough natural GLP-1, or the brain isn't sensitive to it.

Semaglutide is a synthetic GLP-1 RA (receptor agonist). A drug that works as an agonist activates the same cell receptors as the body’s natural hormones. Semaglutide works in the gut like the body’s natural GLP-1, slowing digestion, curbing hunger, and signaling fullness to the brain.

How does it feel to take Semaglutide Plus?
No more random snack cravings throughout the day
Smaller portions feel just as satisfying as large ones used to
The feeling of being full lasts longer after meals
Look great after losing weight by preserving lean muscle

How Willow works

01
Take the quiz
Start with a 2-min assessment quiz to get pre-approved instantly.
02
Choose your plan
Share your health history, choose a plan, and get a same-day prescription from a US doctor.
03
Transform your life
Get monthly weight loss medication with free shipping and support from board-certified doctors.

Our medical team

As a Willow patient, you’ll be supported along your entire weight loss journey by our medical team of board certified doctors.
Have a question? Get answers and guidance with unlimited same-day doctor messaging. Our team is with you every step of the way.
Dr. Michael Green
MD, OB/GYN

Why Willow?

Ready to transform your life with Semaglutide Plus? Willow offers transparent pricing, high-quality medication, and dedicated support.
Only $299 per month, for every dosage. Includes prescription, medication, and free overnight shipping.
Same-day prescriptions with no insurance required.
Unlimited same-day messaging and support from US-based board-certified doctors.

Worried about side effects?

Some patients may experience side effects while on Semaglutide. The most common ones is nausea. While these side effects can be bothersome, the good news is that they usually subside over time.

Your doctor will help find the best treatment, gradually increasing the dosage for weight loss and comfort. If you have any issues, they’ll adjust the plan. Just send a message! — No appointment required.

Your doctor can also prescribe generic Zofran (Ondansetron) if needed. This optional anti-nausea medication can help with side effects.

Game-changing weight loss medication


Results could mark a "new era" in treating obesity with even more therapies on the horizon.


The most effective drug intervention we have seen for weight management.


In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.


2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.


These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.

1
1


Results could mark a "new era" in treating obesity with even more therapies on the horizon.


The most effective drug intervention we have seen for weight management.


In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.


2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.


These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.

1
1


Results could mark a "new era" in treating obesity with even more therapies on the horizon.


The most effective drug intervention we have seen for weight management.


In studies, a weekly injection caused dramatic amounts of weight loss and improved other heart-related risk factors.


2.4 mg of semaglutide once weekly plus lifestyle intervention was associated with sustained, clinically relevant reduction in body weight.


These highly effective anti-obesity medications are associated with weight losses of more than 10% of overall bodyweight in more than two-thirds of clinical trial participants.

1
1

Questions we hear everyday

Do I need to make changes to my diet with Compound Semaglutide?

We believe in a sustainable and flexible approach to nutrition, without imposing limitations on your diet. Our goal is to guide you in establishing healthy eating habits, complemented by the medication's ability to decrease appetite and “food noise”. We encourage maintaining a nourishing, high-protein diet, but most patients are able to lose weight without the need for uncomfortably restrictive dieting or calorie counting.

What are the side effects for Semaglutide?

Common side effects of semaglutide are usually mild and may include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Abdominal pain

• Decreased appetite

• Indigestion


The majority of side effects are transient and typically resolve spontaneously. Nevertheless, if side effects persist or deteriorate, seek guidance from a healthcare professional.

Willow also offers Odansetron to manage side effects if they occur. This medication is commonly used to prevent nausea and vomiting.

Semaglutide Patient Safety Information

What happens if I stop the medication?

When stopping  Semaglutide abruptly, some patients may experience mild to moderate weight gain. Others may maintain the weight loss they achieved while on the medication. We recommend patients work with their Willow physician to slowly decrease their dose in order to maintain their weight loss achievements.

You may notice an increase in appetite and a return of food cravings, allowing you to eat more without feeling as full. However, stopping Semaglutide is a safe and common practice that doesn't involve serious health risks. By gradually tapering off the medication with your physician’s guidance, you can better manage these changes and maintain your health and wellness goals.

How do I take Semaglutide?

Semaglutide is administered once a week via a subcutaneous injection. Don’t worry! The needle is very small and short, making self-injection quick & easy. We’ll provide you with detailed written and video instructions that make the process simple and easy to follow. We even include a link to a soothing Spotify playlist to play in the background if you wish.

More from our members
4.9/5 (2200 + 5 star reviews)
Rachel P.
"Being overweight had me feeling down and anxious all the time. Since starting semaglutide, I’ve lost 28 pounds, but what’s really amazing is how much better I feel mentally. “
Lost  28 lbs
Emily R.
"My weight gain had put a strain on my marriage, and I was feeling disconnected from my partner. Starting semaglutide was the best decision I ever made. I’ve lost 20 pounds, and my confidence has soared. My husband and I are closer than ever, and our relationship feels renewed. Willow didn’t just help me lose weight; they helped me reconnect with my spouse."
Lost  20 lbs
Sophie S.
“I've been on the Willow journey for a few months, and the results speak for themselves. Kudos to the team for a genuinely supportive experience!”
Lost  23 lbs
Tom S.
"Carrying extra weight was making it hard to enjoy hiking and biking, things I love. After starting tirzepatide, I’ve lost 35 pounds and can finally get back to being active. I can keep up with my kids now, which is the best feeling ever. Life feels good again."
Lost  35 lbs
Sarah L.
"Tirzepatide has been a total game-changer for me. In four months, I’ve lost 25 pounds, but the best part is all the extra energy I have now.”
Lost  25 lbs